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. Author manuscript; available in PMC: 2016 Mar 27.
Published in final edited form as: Circ Res. 2015 Feb 5;116(7):e40–e50. doi: 10.1161/CIRCRESAHA.116.304668

Figure 1. Effects of uAMCs, c+AMCs, and MiPSCs on LVEF. Stacks of short axis images acquired by CMR were analyzed offline to determine the LVEF for weeks 1, 2 and 4.

Figure 1

(A) All groups treated with stem cells demonstrated improved LVEF initially compared to control. However, only the MiPSC group demonstrated sustained improvement through week 4. The c+AMC group demonstrated an intermediate restorative effect with significantly improved LVEF compared to control through weeks 1 and 2. The control group showed severely depressed LVEF that was unchanged throughout the study. (B) Short axis acquisitions are shown during end-diastole and end-systole at the mid-LV. The MiPSC treated mouse demonstrated increased contractility compared to control. (*p < 0.05, **p < 0.01 vs. control by unadjusted Student’s t-test.)