Skip to main content
. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Cell Signal. 2015 Feb 26;27(6):1159–1167. doi: 10.1016/j.cellsig.2015.02.020

Figure 10. Proposed model for glucose-stimulated insulin secretion via activation and membrane association of Rac1 and downstream activation of ERK1/2.

Figure 10

We propose that acute exposure of INS-1 832/13 cells to stimulatory glucose (20 mM) results in the activation and membrane association of Rac1. This results in the activation of downstream effectors including ERK1/2, culminating in insulin release from the pancreatic β-cell. Our findings suggest that EHT 1864, a selective inhibitor of Rac1 activation, disrupts this signaling mechanism, thereby attenuating GSIS (see section 4).