Table 1.
Expression of estrogen receptors by immune cells
| Human | Murine | ||||
|---|---|---|---|---|---|
| Cell type | ESR1 (ERα)a | ESR2 (ERβ) | Esr1 (ERα) | Esr2 (ERβ) | References |
| B cell | yes (+++)b | yes (+++) | yes | yes | 2,3,7 |
| CD4+ T cell | yes (++) | yes (++) | yes | c | 2,3,10 |
| CD8+ T cell | yes (++) | yes (++) | 2,3 | ||
| NK cell | yes (++) | yes (++) | yes | yes | 2,8 |
| Plasmacytoid DC | yes (++) | yes (+++) | yes | 2,6 | |
| Monocyte | yes (+) | yes (+) | 2,3 | ||
| Monocyte-derived DC | yes (++) | yes (+) | 2 | ||
| BM-derived DC | yes | yes | 11,12 | ||
| Splenic DC | yes | no | 9 | ||
| Inflammatory DC CNS) | yes | 14 | |||
| Peritoneal Macrophage | yes | no | 9,13 | ||
| BM-derived Macrophage | yes | no | 13 | ||
| Hematopoietic stem cell | yes | yes | yes | no | 18,20 |
| Myeloid progenitor | yes | no | 19 | ||
a
“Yes” indicates either RNA or protein expression, depending on the study. “No” indicates that the RNA or protein was queried but not found.
b
Plus (+) marks indicate relative amounts of RNA determined using quantitative methods in one study [ref 2].
c
Empty cells indicate cell types for which actual data showing ER expression was not readily found in literature searches.