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. Author manuscript; available in PMC: 2016 Apr 24.
Published in final edited form as: J Mol Biol. 2015 Jan 10;427(8):1670–1680. doi: 10.1016/j.jmb.2015.01.002

Table 2.

Comparison of experimental and simulated dimer dissociation constants

pH Kd Exp. (μM)a Kd Sim. (μM)b
7 0.25 1.5
5 N/Ac 0.7
4 1 2.5
2 45 84
a

Experimental Kd values are interpreted from values plotted from analytical ultracentrifugation measurements at 298 K5.

b

The Kd values from simulation are computed at 298 K (0.98 Tm) using Equation 1.

c

No experimental value is available.