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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Curr Opin Cell Biol. 2014 Dec 6;33:49–54. doi: 10.1016/j.ceb.2014.11.002

Figure 1. PPARs and ERRs are major executors of PGC1α-induced regulation of oxidative metabolism.

Figure 1

Physiological stress such as exercise induces both the expression and activity of PGC1α, which stimulates energy production by activating downstream genes involved in fatty acid and glucose metabolism, TCA cycle, β-oxidation, OXPHOS, and mitochondrial biogenesis. The transcriptional activity of PGC1α relies on its interactions with transcriptional factors such as PPARs (for controlling fatty acid metabolism) and ERRs (for regulating mitochondrial OXPHOS).