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. 2015 Apr;185(4):1123–1134. doi: 10.1016/j.ajpath.2014.12.014

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© 2015 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

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Lrig1 is expressed in both Brunner glands (BGs) and overlying epithelium (OE), and Lrig1⁺ cells contribute to tumorigenesis by lineage tracing. A: Immunofluorescence showing Lrig1 (green) expressed in BGs and OE (of which the two compartments were divided by white dashed lines). B: Green fluorescent protein (GFP) immunofluorescence in a duodenal adenoma from an Lrig1-CreERT2/CreERT2;Rosa26R-EYFP/EYFP mouse that was lineage traced for 4 months from 4 weeks of age. DAPI, blue; GFP, white (to visualize EYFP). C and D: Boxed regions in B are magnified. Scale bars: 100 μm. Original magnification: ×5 (C and D).