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. 2015 Apr;185(4):1123–1134. doi: 10.1016/j.ajpath.2014.12.014

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© 2015 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

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A subset of human duodenal tumors exhibits features of LRIG1^−/− adenomas. A and B: Hematoxylin and eosin (H&E) staining of a representative human duodenal adenoma and adenocarcinoma displaying neoplastic cuboidal-shaped foveolar cells. The lesions exhibit gastric metaplasia as determined by MUC6 (C and D) and MUC5AC (E and F) staining, along with increased amphiregulin (AREG) (G and H) and ERBB2 (I and J) immunoreactivity. Boxed regions are magnified in insets (×2.5). Scale bars: 100 μm.