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Human duodenal tumors exhibit enhanced epidermal growth factor receptor (EGFR) activity and loss of LRIG1. A human duodenal adenoma (A–C) and an adenocarcinoma (D–F) (histologic features are shown in Figure 7, A and B, respectively) that were positive for p-EGFR(pY1068) (A and D) but negative for LRIG1 (B and E) immunoreactivity in dysplastic regions. Adjacent normal (Adj NL) areas from an adenoma (C) and an adenocarcinoma (F) exhibited LRIG1 immunoreactivity. Scale bars: 100 μm.
