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. 2015 Apr;185(4):969–986. doi: 10.1016/j.ajpath.2014.12.005

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© 2015 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

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CCG-203971 sensitizes differentiated myofibroblasts to Fas-mediated apoptosis. CCL-210 fibroblasts were treated with/without 2 ng/mL transforming growth factor (TGF)-β1 for 24 hours and then treated with/without 250 ng/mL Fas-activating antibody (Fas-Ab) and/or 30 μmol/L CCG-203971. Apoptosis was assessed by Western blot analysis for poly-(ADP-ribose) polymerase (PARP) (A) and cleavage of a fluorescence substrate by activated caspase-3/7 with image analysis at 8 hours (B). Data are expressed as means ± SEM. n = 3 replicates of each condition with 16 separate images of each replicate analyzed. ^∗∗P < 0.01, ^∗∗∗P < 0.001 versus control; ^†††P < 0.001 versus Fas-Ab + CCG-203971. GAPDH, glyceraldehyde-3-phosphate dehydrogenase.