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. Author manuscript; available in PMC: 2016 Mar 10.
Published in final edited form as: Ann Biomed Eng. 2015 Mar 10;43(3):489–500. doi: 10.1007/s10439-015-1297-4

FIGURE 5.

FIGURE 5

(a) Cellular remodeling and degradation play an important role in regulating the dynamic nature of the ECM. The introduction of hydrogels that degrade in response to cell-secreted enzymes begins to recapitulate this natural process. (b) Patterson et al.47 synthesized PEG hydrogels that were crosslinked with two different peptide sequences that vary in degradation rates. Cells from the aortic chick ring invaded the MMP-degradable network at different rates based on the cleavage rate of the peptide sequence, GPQGIWG (slower) and VPMSMRGG (faster).