Table 1.
Key proteins involved in mitochondrial dynamics and associated disease. Main components of the mitochondrial fusion and fission machineries are indicated in model organisms from algae to mammals. Their location, functions and related diseases are shown.
| Key Mitochondrial dynamics proteins |
Algae | Yeast | Worms | Fly | Mammals | Function | Disease |
|---|---|---|---|---|---|---|---|
|
Dynamin related
protein1 (Drp1) |
Dnm1 | Dnm1 | DRP-1 | Drp1 | Drp1 | OM Fission | Post neonatal death with neurodevelopme ntal defects |
|
Mitochondrial
fission factor (Mff) |
Unknown | Unknown | Mff-1 | Mff-1 | Mff | Drp1 receptor | Unknown |
| MiD49/MiD51 | Unknown | Unknown | Unknown | Unknown | Mid49/Mid51 | Drp1 receptor | Unknown |
|
Fission Protein 1
(Fis1) |
Fis1 | Fis1 | Fis-1 | Fis1 | Fis1 | Drp1 receptor | Unknown |
|
Mdv1/Caf4/Num1/
Mdm36 |
Mda1/-/-/- | Mdv1/Caf4/Num 1/Mdm36 |
Unknown | Unknown | Unknown | Dnm1 adaptor protein |
Unknown |
|
Ganglioside induced
differentiation protein (GDAP1) |
Unknown | Unknown | Unknown | CG4623? | GDAP1 | Unknown | Charcot-Marie- Tooth type 4A |
|
Optic atrophy 1
(Opa1) |
Mgm1 | Mgm1 | EAT-3 | Opa1 | Opa1 | IM Fusion | Autosomal dominant Optic atrophy type 1 |
|
Mitofusin1/2
(Mfn1/2) |
Fzo1 | Fzo1 | Fzo-1 | Fzo1, Marf, dMfn |
Mfn1/Mfn2 | OM fusion | Charcot-Marie- Tooth type 2A |
| Ugo1 | Ugo1 | Ugo1 | Unknown | Unknown | Unknown | OM fusion Links Fzo1 and Mgm1 |
Unknown |