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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Feb 20;1854(5):469–475. doi: 10.1016/j.bbapap.2015.02.007

Fig. 8.

Fig. 8

Proposed PAFAH-II trafficking model. A model of oxidative stress induced trafficking consistent with our observation begins with WT PAFAH-II existing as a homodimer in an unstressed state. The myristoyl group of one subunit packs into the hydrophobic pocket of the dimer partner. Upon ROS oxidative stress, post-translational modification of PAFAH-II disrupts the homodimer, thereby driving the PAFAH-II monomer to seek out a membrane surface for myristoyl group and hydrophobic patch mediated membrane surface interaction.