Table 3.
LHCGR and FSHR genotype frequencies
| 1 / 1 | 1 / 2 | 2 / 2 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Locus | SNP | Cases | Controls | P a | Cases | Controls | aORb (95 % CI) | Cases | Controls | aOR (95 % CI) |
| LHCGR | rs2293275 | 93 (0.46)c | 102 (0.48) | 0.57 | 81 (0.40) | 74 (0.35) | 1.20 (0.79–1.83) | 29 (0.14) | 35 (0.17) | 0.91 (0.52–1.60) |
| rs7371084 | 184 (0.91) | 172 (0.82) | 0.023 | 17 (0.08) | 37 (0.18) | 0.44 (0.24–0.80) | 2 (0.01) | 2 (0.01) | 0.95 (0.13–6.82) | |
| rs4953616 | 70 (0.34) | 103 (0.49) | 0.007 | 91 (0.45) | 81 (0.38) | 1.66 (1.08–2.56) | 42 (0.21) | 27 (0.13) | 2.30 (1.30–4.08) | |
| rs4597581 | 130 (0.64) | 132 (0.63) | 0.86 | 61 (0.30) | 68 (0.32) | 0.91 (0.60–1.39) | 12 (0.06) | 11 (0.05) | 1.13 (0.48–2.64) | |
| rs13405728 | 168 (0.83) | 170 (0.81) | 0.46 | 35 (0.17) | 40 (0.19) | 0.89 (0.53–1.47) | 0 (0.00) | 1 (0.005) | 0.00 (0.00–NA) | |
| rs4073366 | 169 (0.83) | 183 (0.87) | 0.60 | 32 (0.16) | 27 (0.13) | 1.25 (0.72–2.18) | 2 (0.01) | 1 (0.005) | 2.18 (0.20–24.22) | |
| FSHR | rs1007541 | 170 (0.84) | 177 (0.84) | 1.00 | 31 (0.12) | 32 (0.15) | 0.98 (0.57–1.69) | 2 (0.01) | 2 (0.01) | 1.05 (0.06–16.88) |
| rs11692782 | 78 (0.38) | 60 (0.28) | 8.0 × 10−4 | 79 (0.39) | 121 (0.57) | 0.50 (0.32–0.78) | 46 (0.23) | 30 (0.14) | 1.17 (0.66–2.07) | |
| rs2055571 | 75 (0.37) | 69 (0.33) | 0.20 | 80 (0.39) | 102 (0.48) | 0.72 (0.46–1.13) | 48 (0.24) | 40 (0.19) | 1.09 (0.64–1.88) | |
| rs1394205 | 130 (0.64) | 115 (0.55) | 0.08 | 61 (0.30) | 86 (0.41) | 0.63 (0.41–0.96) | 12 (0.06) | 10 (0.05) | 1.08 (0.45–2.59) | |
| rs6166 | 64 (0.32) | 52 (0.26) | 0.31 | 92 (0.45) | 107 (0.51) | 0.70 (0.44–1.12) | 47 (0.23) | 52 (0.26) | 0.74 (0.43–1.27) | |
Genotypes were coded as per “1” = major allele, “2” = minor allele
a2-way ANOVA
baOR = adjusted OR; covariates that were controlled for were BMI, TSH, FT, BT, FAI, SHBG, and fasting insulin
cNumber of subjects (frequency)