Table 3.
Molecular characteristics of colon cancers according to microsatellite status in the two cohorts
| Molecular features | All cases | n (%) | Total CIT (%) | Total Dijon (%) | P value | MSS CIT (%) | MSS Dijon (%) | P value | MSI CIT (%) | MSI Dijon (%) | P value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| PIK3CA status | |||||||||||
| Mutant | 826 | 113 (14) | 59 (14) | 54 (14) | 0.96 | 47 (13) | 43 (13) | 0.99 | 12 (18) | 11 (17) | 0.97 |
| Wild-type | 713 (86) | 374 (86) | 339 (86) | 319 (87) | 284 (87) | 55 (82) | 55 (83) | ||||
| KRAS status | |||||||||||
| Mutant | 817 | 301 (37) | 164 (38) | 137 (35) | 0.37 | 147 (40) | 129 (40) | 0.92 | 17 (27) | 8 (12) | 0.062 |
| Wild-type | 516 (63) | 263 (62) | 253 (65) | 216 (60) | 195 (60) | 47 (73) | 58 (88) | ||||
| BRAF status | |||||||||||
| Mutant | 780 | 85 (11) | 35 (9) | 50 (13) | 0.12 | 7 (2) | 12 (4) | 0.37 | 28 (43) | 38 (58) | 0.11 |
| Wild-type | 695 (89) | 353 (91) | 342 (87) | 316 (98) | 315 (96) | 37 (57) | 27 (42) | ||||
| CIMP status | |||||||||||
| CIMP− | 763 | 606 (79) | 301 (81) | 305 (78) | 0.37 | 278 (90) | 288 (88) | 0.68 | 23 (37) | 17 (26) | 0.26 |
| CIMP+ | 157 (21) | 71 (19) | 86 (22) | 32 (10) | 38 (12) | 39 (63) | 48 (74) | ||||
MSS, microsatellite stable; MSI, microsatellite instable; CIMP, CpG island methylator phenotype.