Table 4.
Clinical, pathological, and molecular characteristics of tumors according to PIK3CA and microsatellite status in the two cohorts
| Features | MSS tumors | MSI tumors | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CIT cohort | P value | Dijon cohort | P value | CIT cohort | P value | Dijon cohort | P value | |||||
| PIK3CAm | PIK3CAwt | PIK3CAm | PIK3CAwt | PIK3CAm | PIK3CAwt | PIK3CAm | PIK3CAwt | |||||
| Gender | ||||||||||||
| Female | 18 (38) | 138 (43) | 0.63 | 24 (56) | 106 (37) | 0.032 | 6 (50) | 27 (49) | 0.79 | 7 (64) | 35 (64) | 0.73 |
| Male | 29 (62) | 181 (57) | 19 (44) | 178 (63) | 6 (50) | 28 (51) | 4 (36) | 20 (36) | ||||
| Age (years)1 | 69 [25–96] | 69 [37–96] | 0.62 | 73 [49–94] | 73 [36–95] | 0.75 | 70 [32–88] | 75 [24–92] | 0.093 | 77 [67–88] | 80 [33–91] | 0.78 |
| TNM.stage | ||||||||||||
| I | 3 (7) | 22 (7) | 0.54 | 5 (12) | 30 (11) | 0.19 | 4 (33) | 4 (7) | 0.034 | 1 (9) | 7 (13) | 0.89 |
| II | 26 (55) | 149 (47) | 28 (65) | 148 (52) | 4 (33) | 32 (58) | 8 (73) | 36 (65) | ||||
| III | 18 (38) | 148 (46) | 10 (23) | 106 (37) | 4 (33) | 19 (35) | 2 (18) | 12 (22) | ||||
| Tumor.location | ||||||||||||
| Distal | 23 (49) | 211 (66) | 0.033 | 23 (53) | 191 (67) | 0.11 | 2 (17) | 13 (24) | 0.89 | 0 (0) | 9 (16) | 0.34 |
| Proximal | 24 (51) | 108 (34) | 20 (47) | 93 (33) | 10 (83) | 42 (76) | 11 (100) | 46 (84) | ||||
| Adjuvant CT | ||||||||||||
| No | 28 (60) | 175 (55) | 0.65 | 32 (74) | 190 (67) | 0.45 | 10 (83) | 44 (81) | 0.79 | 10 (91) | 51 (93) | 0.68 |
| Yes | 19 (40) | 144 (45) | 11 (26) | 92 (33) | 2 (17) | 10 (19) | 1 (9) | 4 (7) | ||||
| KRAS status | ||||||||||||
| Mutant | 22 (48) | 125 (39) | 0.36 | 25 (58) | 104 (37) | 0.014 | 6 (55) | 11 (21) | 0.053 | 2 (18) | 6 (11) | 0.87 |
| Wild-type | 24 (52) | 192 (61) | 18 (42) | 177 (63) | 4 (45) | 42 (79) | 9 (82) | 49 (89) | ||||
| BRAF status | ||||||||||||
| Mutant | 1 (2) | 6 (2) | 0.6 | 1 (2) | 11 (4) | 0.95 | 3 (27) | 25 (46) | 0.41 | 6 (55) | 32 (59) | 0.96 |
| Wild-type | 46 (98) | 270 (98) | 42 (98) | 273 (96) | 8 (73) | 29 (54) | 5 (45) | 22 (41) | ||||
| CIMP status | ||||||||||||
| CIMP− | 33 (77) | 245 (92) | 0.0063 | 37 (86) | 251 (89) | 0.8 | 5 (50) | 18 (35) | 0.57 | 3 (27) | 14 (26) | 1 |
| CIMP+ | 10 (23) | 22 (8) | 6 (14) | 32 (11) | 5 (50) | 34 (65) | 8 (73) | 40 (74) | ||||
CT, chemotherapy; m, mutated; wt, wild-type. Figures in brackets represent the percentages.
1
Median [range].