Table 5.
Cox proportional hazards model for RFI among microsatellite stable tumors in the two cohorts
| Variables | Univariate analysis | Multivariate analysis1 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| n | n events | HR | 95% CI | P value | n | HR | 95% CI | P value | |
| CIT cohort | |||||||||
| TNM stage | |||||||||
| II | 366 | 99 | 5.1 | 0.7–38 | 0.11 | 366 | 5.4 | 0.74–39 | 0.096 |
| III | 366 | 99 | 11 | 1.5–77 | 0.019 | 11 | 1.5–80 | 0.017 | |
| PIK3CA | |||||||||
| Mutated | 366 | 99 | 0.12 | 0.029–0.48 | 0.0029 | 0.12 | 0.029–0.48 | 0.0027 | |
| Gender | |||||||||
| Male | 366 | 99 | 1.1 | 0.73–1.6 | 0.67 | ||||
| Age | |||||||||
| – | 365 | 99 | 1 | 0.98–1 | 0.84 | ||||
| Tumor location | |||||||||
| Proximal colon | 366 | 99 | 1 | 0.66–1.5 | 0.99 | ||||
| KRAS | |||||||||
| Mutated | 363 | 99 | 1.2 | 0.81–1.8 | 0.37 | ||||
| BRAF | |||||||||
| Mutated | 323 | 78 | 1.5 | 0.36–6 | 0.6 | ||||
| CIMP | |||||||||
| CIMP+ | 310 | 74 | 0.98 | 0.45–2.1 | 0.95 | ||||
| Dijon cohort | |||||||||
| TNM stage | |||||||||
| II | 327 | 97 | 2.5 | 0.89–6.8 | 0.084 | 327 | 2.5 | 0.89–6.8 | 0.084 |
| III | 327 | 97 | 4.2 | 1.5–12 | 0.0058 | 4.2 | 1.5–12 | 0.0058 | |
| PIK3CA | |||||||||
| Mutated | 327 | 97 | 0.45 | 0.21–0.97 | 0.042 | 0.49 | 0.23–1.1 | 0.074 | |
| Gender | |||||||||
| Male | 327 | 97 | 1.1 | 0.71–1.6 | 0.77 | ||||
| Age | |||||||||
| - | 327 | 97 | 0.99 | 0.98–1 | 0.46 | ||||
| Tumor location | |||||||||
| Proximal colon | 327 | 97 | 0.7 | 0.44–1.1 | 0.11 | ||||
| KRAS | |||||||||
| Mutated | 324 | 95 | 1.3 | 0.86–1.9 | 0.22 | ||||
| BRAF | |||||||||
| Mutated | 327 | 97 | 0.31 | 0.043–2.2 | 0.24 | ||||
| CIMP | |||||||||
| CIMP+ | 326 | 97 | 0.89 | 0.45–1.8 | 0.75 | ||||
CIMP, CpG island methylator phenotype; HR, hazard ratio; CI, confidence interval; P value, Wald test P value.
1
Multivariate models include significant variables (P < 0.05).