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Schematic representation of protomer assembly for R67 DHFR variants. (a) Assembly of the native, monomeric R67 DHFR into a tetramer with a central active-site pore. (b) Assembly of a dimer of dimers, where the red protomers are mutated. (c) Putative assembly of a trimer of dimers to yield an active-site where only one protomer is mutated.
