Table IV.
Sequence Binning Results Obtained by Backbone Drift Modeling
| Success rate (%) | True positive | False negative | False positive | True negative | Cutoff (kcal/mol) | |
|---|---|---|---|---|---|---|
| ROMXTALa | 92 | 20 | 4 | 3 | 57 | −74.8 |
| ROMNMRa | 81 | 12 | 12 | 4 | 56 | −76.5 |
| PDBb | 86 | 12 | 12 | 0 | 60 | −78.4 |
a
ROM templates were prepared using stabilizing sequences.
b
Set includes 17 Gβ1 depositions available in the Protein Data Bank: 1EM7, 1IGD, 1PGA,1PGB, 2GB1, 2IGD, 2IGH, 2J52, 2J53, 2K0P, 2LGI, 2RMM(chain-A), 2RMM(chain-B), 2RPV, 3GB1, 3MP9(chain-A), 3MP9(chain-B).