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Dehydration causes a depolarizing shift in EGABA through a bumetanide-sensitive mechanism. Whole-cell recordings show that 3 d of dehydration causes a depolarizing shift in EGABA (p < 0.001). A bath application of bumetanide (50–100 μm) partially but significantly reversed the dehydration-induced polarizing shift (p < 0.05). Top traces are from holding potentials as −78, −68, −58, −48, and −38 mV. Calibration: 20 pA and 10 ms.
