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. 2015 Mar 3;43(6):3056–3067. doi: 10.1093/nar/gkv144

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Cohesin is enriched at the promoters of actively transcribed genes. (A) Transcriptional profiles from the cortex (left) and pancreas (right) of 10-week-old mice were determined by RNA-seq. Tissue-specific genes were selected for each tissue (see main text for details) and further confirmed by Gene Ontology analysis. (B) Cohesin distribution around the TSS (±6 kb) of genes expressed specifically in cortex (upper panels) and pancreas (lower panels) defined as peak frequency (%). Both SMC1 and SA1 distributions are shown. (C) Gene expression changes between wild-type and SA1 null brains (KO) from E17.5 embryos were characterized by RNA-seq (FDR < 0.05). (D) Cohesin distribution around the TSS of genes found to be down-regulated (left) and up-regulated (right) in SA1 null embryonic brains.