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Proposed model of translation termination by eRF1. The stop codon is recognized by eRF1 in complex with eRF3. Following GTP hydrolysis, eRF3 is released and replaced by ABCE1, inducing changes in the conformation of the eRF1 N domain. These structural changes allow the stop codon to interact with the P1 pocket and the GGQ motif to be in close proximity to the CCA end of the P-site tRNA for the induction of peptide release before ribosome dissociation.
