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. 2015 Mar 9;43(6):3154–3166. doi: 10.1093/nar/gkv160

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — ATM inhibition after end resection results in higher numbers of residual RAD51/γH2AX foci in both S and G2 cells. (A) A549 cells were EdU pulse labeled, irradiated with 2 Gy and the kinetics of RAD51 foci numbers were monitored in CenpF⁺/EdU⁻ G2-cells at the indicated time points. (B) γH2AX foci were evaluated at the indicated time points in CenpF⁺/EdU⁻ G2-cells. (C) The kinetics of RAD51 foci numbers were monitored in CenpF⁺/EdU⁺ S-cells at the indicated time points. (D) γH2AX foci were evaluated in CenpF⁺/EdU⁺ S-cells at the indicated time points. In all cases, the number of foci measured in non-irradiated cells was subtracted from that observed in irradiated cells. Error bars represent the SEM of three independent experiments.