Table 1. Coefficient and weight of each gene for 5-FU, oxaliplatin and SN38.
| Column ID | Coefficient | Weights (wi) | Gene symbol | Gene title | HR | 95% CI | P-value |
|---|---|---|---|---|---|---|---|
| 5-FU | |||||||
| 201560_at | 1.00 | 0.075 | CLIC4 | Chloride intracellular channel 4 | 2.72 | 1.48–4.99 | 1.3E-03 |
| 225681_at | 0.60 | 0.268 | CTHRC1 | Collagen triple-helix repeat containing 1 | 1.82 | 1.24–2.67 | 2.2E-03 |
| 201852_x_at | 0.96 | 0.138 | COL3A1 | Collagen, type III, alpha 1 | 2.61 | 1.4–4.86 | 2.6E-03 |
| 60474_at | −0.72 | −0.614 | FERMT1 | Fermitin family homolog 1 (Drosophila) | 0.49 | 0.3–0.78 | 3.0E-03 |
| 226552_at | 0.96 | 0.083 | IER5L | Immediate early response 5-like | 2.62 | 1.36–5.01 | 3.8E-03 |
| 201508_at | 0.81 | 0.062 | IGFBP4 | Insulin-like growth factor-binding protein 4 | 2.25 | 1.28–3.94 | 4.8E-03 |
| 219744_at | −3.61 | −0.019 | FN3K | Fructosamine 3 kinase | 0.03 | 0.002–0.35 | 5.6E-03 |
| 227915_at | −2.23 | −0.027 | ASB2 | Ankyrin repeat and SOCS box-containing 2 | 0.11 | 0.02–0.54 | 6.9E-03 |
| 205249_at | 0.66 | 0.151 | EGR2 | Early growth response 2 | 1.94 | 1.18–3.18 | 8.7E-03 |
| 205708_s_at | −1.06 | −0.111 | TRPM2 | Transient receptor potential cation channel, subfamily M, member 2 | 0.35 | 0.15–0.77 | 9.3E-03 |
| Probe set ID | Coefficient | Weights (wi) | Gene symbol | Gene title | HR | 95% CI | P-value |
| Oxaliplatin | |||||||
| 226497_s_at | 1.50 | 0.435 | FLT1 | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability | 4.50 | 2.49–8.13 | 5.9E-07 |
| 202436_s_at | 0.48 | 0.233 | CYP1B1 | Cytochrome P450, family 1, subfamily B, polypeptide 1 | 1.61 | 1.32–1.97 | 3.0E-06 |
| 205304_s_at | 1.70 | 0.136 | KCNJ8 | Potassium inwardly-rectifying channel, subfamily J, member 8 | 5.46 | 2.5–11.94 | 2.1E-05 |
| 212607_at | 1.00 | 0.001 | AKT3 | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 2.72 | 1.64–4.52 | 1.1E-04 |
| 204596_s_at | 1.26 | 0.362 | STC1 | Stanniocalcin 1 | 3.51 | 1.81–6.84 | 2.2E-04 |
| 205003_at | 0.90 | 0.216 | DOCK4 | Dedicator of cytokinesis 4 | 2.47 | 1.45–4.18 | 8.1E-04 |
| 202729_s_at | 0.96 | −0.099 | LTBP1 | Latent-transforming growth factor beta-binding protein 1 | 2.60 | 1.47–4.6 | 1.0E-03 |
| 200984_s_at | 1.28 | 0.106 | CD59 | CD59 molecule, complement regulatory protein | 3.58 | 1.67–7.68 | 1.0E-03 |
| 217762_s_at | 0.58 | −0.137 | RAB31 | RAB31, member RAS oncogene family | 1.78 | 1.25–2.55 | 1.5E-03 |
| 207714_s_at | 0.87 | 0.059 | SERPINH1 | Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1 (collagen bindin | 2.38 | 1.39–4.05 | 1.5E-03 |
| 217763_s_at | 0.54 | −0.143 | RAB31 | RAB31, member RAS oncogene family | 1.72 | 1.2–2.46 | 3.1E-03 |
| 209087_x_at | 1.35 | 0.123 | MCAM | Melanoma cell adhesion molecule | 3.84 | 1.53–9.64 | 4.2E-03 |
| 226923_at | −1.58 | −0.207 | SCFD2 | sec1 family domain containing 2 | 0.21 | 0.07–0.63 | 5.3E-03 |
| 201420_s_at | −1.11 | −0.006 | WDR77 | WD repeat domain 77 | 0.33 | 0.15–0.72 | 5.7E-03 |
| 212045_at | 1.57 | 0.039 | GLG1 | Golgi glycoprotein 1 | 4.82 | 1.58–14.72 | 5.8E-03 |
| 209209_s_at | 0.52 | 0.110 | FERMT2 | Fermitin family homolog 2 (Drosophila) | 1.68 | 1.15–2.44 | 6.6E-03 |
| 225946_at | 0.53 | 0.038 | RASSF8 | Ras association (RalGDS/AF-6) domain family (N terminal) member 8 | 1.71 | 1.16–2.52 | 7.0E-03 |
| 226314_at | 1.54 | 0.030 | CHST14 | Carbohydrate (N-acetylgalactosamine 4–0) sulfotransferase 14 | 4.67 | 1.5–14.56 | 7.9E-03 |
| Column ID | Coefficient | Weights (wi) | Gene symbol | Gene title | HR | 95% CI | P-value |
| SN38 | |||||||
| 227123_at | 1.71 | 0.379 | RAB3B | RAB3B, member RAS oncogene family | 5.54 | 2.68–11.46 | 3.8E-06 |
| 211924_s_at | 1.12 | 0.589 | PLAUR | Plasminogen activator, urokinase receptor | 3.06 | 1.74–5.38 | 1.1E-04 |
| 203382_s_at | 0.67 | 0.496 | APOE | Apolipoprotein E | 1.96 | 1.38–2.78 | 1.7E-04 |
| 210512_s_at | 1.34 | 1.256 | VEGFA | Vascular endothelial growth factor A | 3.83 | 1.86–7.88 | 2.7E-04 |
| 220003_at | −2.91 | −0.681 | LRRC36 | Leucine-rich repeat containing 36 | 0.05 | 0.01–0.29 | 5.8E-04 |
| 202068_s_at | 1.07 | 1.007 | LDLR | Low-density lipoprotein receptor | 2.91 | 1.56–5.45 | 8.3E-04 |
| 206439_at | 0.27 | 0.227 | EPYC | Epiphycan | 1.31 | 1.11–1.53 | 1.1E-03 |
| 212119_at | 1.43 | −0.259 | RHOQ | ras homolog gene family, member Q | 4.18 | 1.75–9.99 | 1.3E-03 |
| 220987_s_at | −1.16 | −0.187 | NUAK2 | NUAK family, SNF1-like kinase, 2 | 0.31 | 0.15–0.64 | 1.5E-03 |
| 204298_s_at | 0.46 | −0.371 | LOX | Lysyl oxidase | 1.59 | 1.19–2.11 | 1.7E-03 |
| 1553984_s_at | −1.27 | −0.437 | DTYMK | Deoxythymidylate kinase (thymidylate kinase) | 0.28 | 0.12–0.64 | 2.4E-03 |
| 214211_at | 0.86 | −0.137 | FTH1 | Ferritin, heavy polypeptide 1 | 2.35 | 1.33–4.16 | 3.2E-03 |
| 204589_at | 0.67 | −0.378 | NUAK1 | NUAK family, SNF1-like kinase, 1 | 1.96 | 1.23–3.15 | 5.1E-03 |
| 227610_at | −1.73 | −0.387 | TSPAN11 | Tetraspanin 11 | 0.18 | 0.05–0.62 | 6.7E-03 |
| 222696_at | −0.37 | −0.118 | AXIN2 | Axin 2 | 0.69 | 0.53–0.9 | 6.9E-03 |
| 227279_at | 0.88 | −0.394 | TCEAL3 | Transcription elongation factor A (SII)-like 3 | 2.42 | 1.25–4.68 | 8.5E-03 |
| 1553396_a_at | −1.05 | 0.010 | CCDC13 | Coiled-coil domain containing 13 | 0.35 | 0.16–0.77 | 8.6E-03 |
| 224867_at | −1.11 | −0.953 | C1orf151 | Chromosome 1 open-reading frame 151 | 0.33 | 0.14–0.75 | 8.6E-03 |
| 200098_s_at | −1.55 | −0.317 | ANAPC5 | Anaphase-promoting complex subunit 5 | 0.21 | 0.07–0.68 | 9.3E-03 |
Abbreviations: CI, confidence interval; 5-FU, 5-fluorouracil; HR, hazard ratio.