Table 1.
Prechemotherapy clinicopathological characteristics
| Characteristic | Low p53 No. (%) | High p53 No. (%) | p-value | Low Ki-67 No. (%) | High Ki-67 No. (%) | p-value | Bcl-2 (-) No. (%) | Bcl-2 (+) No. (%) | p-value |
|---|---|---|---|---|---|---|---|---|---|
| Age (yr)* | 41.9 ± 9.9 | 43.6 ± 9.8 | 0.319 | 43.6 ± 10.4 | 42.9 ± 9.8 | 0.705 | 44.1 ± 9.9 | 41.4 ± 9.5 | 0.115 |
| Initial tumor size (cm) | 0.32 | 0.26 | 0.571 | ||||||
| <3 | 20 (22.7) | 34 (31.8) | 7 (20.6) | 46 (28.9) | 35 (29.9) | 20 (25.6) | |||
| 3-5 | 37 (42.0) | 43 (40.2) | 14 (41.2) | 65 (40.9) | 46 (39.3) | 33 (42.3) | |||
| > 5 | 31 (35.2) | 30 (28.0) | 13 (38.2) | 48 (30.2) | 36 (30.8) | 25 (32.1) | |||
| Continuous† | 4.5 ± 1.8 | 4.4 ± 2.0 | 0.521 | 4.7 ± 2.2 | 4.3 ± 1.8 | 0.523 | 4.5 ± 2.0 | 4.3 ± 1.7 | 0.529 |
| Initial N stage | 0.662 | 0.528 | 0.547 | ||||||
| N0 | 3 (3.4) | 2 (1.9) | 2 (5.9) | 3 (1.9) | 3 (2.6) | 2 (2.6) | |||
| N1 | 44 (50.0) | 63 (58.9) | 17 (50.0) | 89 (56.0) | 63 (53.8) | 44 (56.4) | |||
| N2 | 30 (34.1) | 25 (23.4) | 9 (26.5) | 45 (28.3) | 33 (28.2) | 22 (28.2) | |||
| N3 | 11 (12.5) | 17 (15.9) | 6 (17.6) | 22 (13.8) | 18 (15.4) | 10 (12.8) | |||
| Initial c stage | 0.382 | 0.875 | 0.429 | ||||||
| IIA | 5 (5.7) | 3 (2.8) | 1 (2.9) | 7 (4.4) | 3 (2.6) | 5 (6.4) | |||
| IIB | 25 (28.4) | 37 (34.6) | 12 (35.3) | 49 (30.8) | 38 (32.5) | 24 (30.8) | |||
| IIIA | 37 (42.0) | 40 (37.4) | 11 (32.4) | 65 (40.9) | 46 (39.3) | 31 (39.7) | |||
| IIIB | 9 (10.2) | 9 (8.4) | 4 (11.8) | 14 (8.8) | 11 (9.4) | 7 (9.0) | |||
| IIIC | 12 (13.6) | 18 (16.8) | 6 (17.6) | 24 (15.1) | 19 (16.2) | 11 (14.1) | |||
| Histology | 0.15 | 0.285 | 0.468 | ||||||
| Ductal | 83 (94.3) | 106 (99.1) | 32 (94.1) | 155 (97.1) | 112 (95.7) | 77 (98.7) | |||
| Others | 5 (5.7) | 1 (0.9) | 2 (5.9) | 4 (2.5) | 5 (4.3) | 1 (1.3) | |||
| Histologic grade | 0.095 | 0.35 | 0.454 | ||||||
| I/II | 10 (11.4) | 9 (8.4) | 6 (17.6) | 13 (8.2) | 11 (10.8) | 8 (12.1) | |||
| III | 70 (79.5) | 79 (73.8) | 27 (79.4) | 120 (75.5) | 91 (89.2) | 57 (86.4) | |||
| Unknown | 8 (9.1) | 19 (17.8) | 1 (2.9) | 26 (16.4) | 15 (12.8) | 13 (16.7) | |||
| Nuclear grade | 0.076 | 0.425 | 0.385 | ||||||
| I/II | 23 (26.1) | 13 (12.1) | 8 (24.2) | 28 (21.1) | 25 (24.5) | 11 (16.9) | |||
| III | 57 (64.8) | 75 (70.1) | 25 (75.8) | 105 (78.9) | 77 (75.5) | 54 (83.1) | |||
| Unknown | 8 (9.1) | 19 (17.8) | 1 (2.9) | 26 (16.4) | 15 (12.8) | 13 (16.7) |
*Mean±SD; †Entered as continuous variable.