Table 1.
Histological features in hepatitis C virus infected hemodialysis patients
| Ref. | Study design/ country | No. of patients | Control group | Histological features | Milder histology in HD as conclusion |
| Barril[50] | Multicenter observational/ Spain | n = 218 HD pts | None | 70% chronic hepatitis 3% steatosis 15% cirrhosis | (+/-) |
| Rebiopsy after 7 yr (n = 181) | 74% stable disease 11% progression | ||||
| Trevizoli et al[48] | Case-control study/Brasil | n = 36 aHCV(+) HD pts | n = 37 aHCV(+) with normal renal function | HD pts vs control group: Hepatic fibrosis 47.2% vs 73% (P < 0.025) Inflammatory activity 27.7% vs 59.5 % (P = 0.003) | (++) |
| Mysorekar et al[51] | Observational/ India | n = 45 aHCV(+) HD pts | None | 67% (n = 30/45) mild inflammatory activity+mild fibrosis (stage 0, 1, 2) | (+/-) |
| Sterling et al[31] | Prospective case-contrrol study/United States | n = 50 aHCV(+) HD pts (transplant candidates) | Two A.Normal renal function, normal ALT (n = 43) B.Normal renal function, ↑ALT (n = 43) | Advanced liver disease (bridging fibrosis/cirrhosis) in 22% of HD pts vs 12% in group A (NS) and 48% in group B (P < 0.001) Mild hepatic inflammation in 62% of HD pts (score1-3) vs 36% in control groups A and B (P < 0.0001) | (++) |
| Cotler et al[30] | Case-control study/United States | n = 46 aHCV(+) HD pts | n = 46 aHCV (+) with normal renal function | HD pts vs control group: Less inflammatory activity (P < 0.001) Less bridging fibrosis/cirrhosis (13% vs 30%, P = 0.043) | (++) |
| Aslinia et al[49] | Cross sectional/United States | n = 156 aHCV(+) HD pts | n = 138 aHCV(+) with normal renal function | HD pts vs control group: Less necroinflammation (P < 0.05) Less fibrosis (P < 0.0001) | (++) |
| Becker et al[19] | Brasil | n = 216 aHCV(+) HD pts | None | 77% absence of septal fibrosis (F0, F1) 12% F2 7% F3 | (+) |
| Sakellariou et al[18] | Comparative analysis/Greece | n = 61 aHCV(+) HD pts | n = 326 non-HD, aHCV(+) pts | 4% cirrhosis HD pts vs control group: Milder stage (P = 0.033) Lower grade (periportal activity, portal inflammation, lobular activity) (P < 0.001) Lower frequency of: Lymphoid aggregates (10.2% vs 50%, P < 0.001) Bile duct lesions (1.7% vs 22.1%, P < 0.001) Less extent of steatosis in HD pts (P = 0.022) | (++) |
HD: Hemodialysis; HCV: Hepatitis C virus; ALT: Aminotransferase.