Table 4.
Combination therapy | Ref. | No. of patients | Dose | Duration | SVR (%) | Withdrawal rate (%) |
IFN-α + RBV | Mousa et al[78] | 20 | 3 MU (IFN) + 200 mg (RBV) 3 times per week | 24 wk (n = 9) | 67 | 0 |
3 MU (IFN) + 200 mg (RBV) 3 times per week | 48 wk (n = 11) | 36 | 0 | |||
PegIFN-α + RBV | Rendina et al[79] | 35 | 135 μg/wk (Peg-IFN-a-2a) + 200 mg/qd (RBV) | 48 wk (gtp 1) | 97 | 14 |
24 wk (non-gtp 1) | ||||||
PegIFN-α + RBV | Carriero et al[80] | 14 | 135 μg/wk (Peg-IFN-a-2a) + 200 mg/qd(RBV) | 48 wk | 29 | 71 |
PegIFN-α + RBV | Hakim et al[81] | 15 | 135 μg/wk (Peg-IFN-a-2a) + 200 mg/wk to 3 times per week (RBV) | 48 wk | 7 | 33 |
PegIFN-α + RBV | Liu et al[82] | 35 | 135 μg/wk (Peg-IFN-a-2a) + 200 mg/qd (RBV) | 48 wk (gtp 1) | ||
24 wk (non-gtp 1) | 60 | 17 |
IFN-α: Interferon-α; PegIFN-α: Pegylated interferon-α; RBV: Ribavirin.