Table 4.

Representative mutations and clinical characteristics

Region	Mutation	Clinical characteristics
Pre-S/S	P120S/E, K122R, T126A, P127T, Q129H/R, L134S, K141E, P142S, D144A/E/V, G145R/A	OBI/HBsAg decrease
	Pre-S deletion	HCC
Pre-C/C	A1896T, G1899A	HBe seroconversion HCC
X	C1653T, T1753C, A1762T, G1764A	HCC
P	L180M, A181V, T184G, S202I, M204V/I N236T, M250V	NA resistance

S: Surface; OBI: Occult hepatitis B virus infection; HCC: Hepatocellular carcinoma; HBe: Hepatitis B e; HBsAg: Hepatitis B s antigen.