Table 3.

Cross-sectional association between blood pressure and magnetic resonance imaging (MRI) brain measures

	Visual measuresa		Automated measuresa
	ORb (95% CI)	P	β-value (s.e.)	P
Global atrophy
Normotensive	1.0 (reference)		0.0 (reference)
Controlled	0.8 (0.3–2.0)	0.6	–41027.6 (24635.2)	0.1
Untreated	1.4 (0.7–3.0)	0.4	–22930.0 (20052.8)	0.3
Poorly controlled	1.0 (0.4–2.4)	0.9	–29300.7 (23651.9)	0.2
Left hippocampus
Normotensive	1.0 (reference)		0.0 (reference)
Controlled	1.3 (0.4–4.3)	0.6	–0.010 (0.008)	0.2
Untreated	1.2 (0.5–3.3)	0.7	–0.007 (0.006)	0.3
Poorly controlled	2.2 (0.8–6.3)	0.1	–0.003 (0.007)	0.7
Right hippocampus
Normotensive	1.0 (reference)		0.0 (reference)
Controlled	1.4 (0.4–5.0)	0.6	0.0003 (0.007)	1.0
Untreated	1.0 (0.3–3.1)	1.0	–0.005 (0.006)	0.4
Poorly controlled	3.1 (1.0–9.1)	0.04	–0.006 (0.007)	0.4
White matter, deep
Normotensive	1.0 (reference)		N/A	N/A
Controlled	3.8 (1.3–11.1)	0.01
Untreated	3.7 (1.5–9.0)	0.005
Poorly controlled	4.4 (1.6–11.9)	0.004
White matter, periventricular
Normotensive	1.0 (reference)	0.1	N/A	N/A
Controlled	2.1 (0.8–5.3)	0.2
Untreated	1.6 (0.7–3.4)	0.08
Poorly controlled	2.2 (0.9–5.3)
White matter, Fazekas/total
Normotensive	1.0 (reference)		0.0 (reference)
Controlled	2.5 (1.0–6.4)	0.05	0.4 (0.2)	0.009
Untreated	2.0 (0.9–4.1)	0.07	0.4 (0.1)	0.002
Poorly controlled	3.6 (1.4–8.9)	0.007	0.5 (0.1)	0.0005

^a.Adjusted for age and gender.

^b.Odds ratios associated with a 10 mmHg increment in average blood pressure.