Table 1.
Relative risks and 95% confidence intervals of depression, by randomised groupa
| Total cases/person years (event rate, per 1000 person-years) |
|||||
| All | Active group | Placebo group | Relative risk of depressionb (95% CI) | P | |
| Primary analysis | 524/28 467 (18.4) | 265/14 285 (18.6) | 259/14 183 (18.3) | 1.02 (0.86–1.21) | 0.81 |
| Adherence analysisc | 412/23 306 (17.7) | 204/11 703 (17.4) | 208/11 603 (17.9) | 0.98 (0.81–1.19) | 0.82 |
| Stratified by age, years | |||||
| Aged <65 | 350/15 335 (22.8) | 183/7 755 (23.6) | 167/7 580 (22.0) | 1.09 (0.88–1.34) | 0.44 |
| Aged ≥65 | 174/13 133 (13.2) | 82/6 530 (12.6) | 92/6 603 (13.9) | 0.90 (0.67–1.21) | 0.48 |
a.
Comparing active agent to placebo.
b.
Adjusted for age (continuous, in years) and other randomised agents.
c.
Sensitivity analysis: each participant was censored at the year of her first follow-up report of taking <67% of study pills (i.e. low adherence with study pills).