Table 2.

Relative risks and 95% confidence intervals of clinical depression, according to stratified subgroups^a

Stratified factors	Participants with depression, n	Relative risks of depression	P for interaction
Age group, years			0.31
<65	350	1.09 (0.88–1.34)
≥65	174	0.90 (0.67–1.21)
Vitamin C agent			0.91
No	226	1.03 (0.80–1.34)
Yes	298	1.01 (0.81–1.27)
Vitamin E agent			0.49
No	275	0.97 (0.76–1.22)
Yes	249	1.09 (0.85–1.39)
Beta-carotene agent			0.24
No	233	1.15 (0.89–1.48)
Yes	291	0.93 (0.74–1.17)
Low folate (<279 μg/d) intake			0.07
No	409	0.93 (0.77–1.13)
Yes	89	1.41 (0.92–2.14)
Low B6 (<1.9 mg/d) intake			0.63
No	366	0.98 (0.80–1.20)
Yes	132	1.07 (0.76–1.51)
Low B12 (<2.4 μg/d) intake			0.67
No	478	1.01 (0.85–1.21)
Yes	20	0.84 (0.34–2.05)
Low intake of any nutrient (folate, B6 or B12)			0.75
No	346	0.99 (0.80–1.22)
Yes	152	1.04 (0.76–1.43)
Daily alcohol intake			0.80
No	488	1.03 (0.86–1.23)
Yes	36	0.99 (0.51–1.91)
Charlson score			0.75
<2	242	1.06 (0.82–1.36)
≥2	282	1.00 (0.79–1.26)

^a.Adjusted for age (continuous, in years) and other randomised agents.