Figure 3.

p53 acetyltransferases are targeted by multiple proteins that regulate their function. Schematic of p53 highlighting its acetylation by six different histone acetyltransferases, p300/CBP, PCAF, Tip60, MOF, and MOZ. The ability of these acetyltransferases to regulate p53 is influenced both positively (arrows) and negatively (perpendicular bars) by many types of proteins, including the indicated viral proteins, ubiquitin ligases, kinases, and other cellular factors. TAD, transactivation domain; TET, tetramerization domain, REG, regulatory domain.