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. 2015 Mar 17;16(1):192. doi: 10.1186/s12864-015-1399-2

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© Hernando et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Analysis of the effects of PRMT5 and PRMT4s on constitutive pre-mRNA splicing. (A) Overlap between introns with increased retention in both mutants. (B) Representation Factor of introns whose retention increased simultaneously in prmt5 and prmt4a;4b in the selected functional categories. *: indicates over-representation compared to random, representation factor significance was assessed using a hypergeometric test (p ≤ 0,05). (C) Splicing Ratios of some representative events showing increased inclusion in both mutants is displayed (FDR ≤0,1). The GO category to which each gene belongs is indicated at the bottom of each panel.