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. 2015 Mar 17;15:135. doi: 10.1186/s12885-015-1138-8

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© Gambaro et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effects of IGFBP7 recombinant protein on EOC cell lines. A, Western blot analysis showing an alteration of the phophorylation status of ERK and AKT proteins after rIGFBP7 treatment of 1 ng/μl of OV90 neo^r cell line as determined at different time points following exposure. Total AKT and total ERK served as a loading control. B, Spheroid formation assay with OV90 neo^r and TOV112D cell lines in the presence or absence of rIGFBP7 (1 and 10 ng/μl). Images are shown at ×20 magnification. C, wound healing assay of OV90 neo^r and TOV112D in the presence or absence of rIGFBP7 (1 and 5 ng/μl) observed over a period of 6 days. Images are shown at × 10 magnification.