Table 3.
Regional differences in grey matter volume between individuals with AD and HC
| Region | Maximum | Cluster | Jackknife sensitivity analysis (combination of studies detecting the differences) | |||
|---|---|---|---|---|---|---|
| MNI coordinates x y z | SDM value | P value | Number of voxels | Clusters breakdown (no. of voxels) | ||
| Left parahippocampl gyrus, BA36 | −30,-10,-28 | −6.544 | ~0 | 3440 | Left parahippocampal gyrus (676) | 30 out of 30 |
| Left insula (515) | ||||||
| Left temporal gyrus (879) | ||||||
| Left hippocampus (706) | ||||||
| Left inferior frontal gyrus (450) | ||||||
| Left rolandic operculum (214) | ||||||
| Right fusiform gyrus | 34,-8,-30 | −6.257 | ~0 | 5838 | Right temporal gyrus (3300) | 29 out of 30 |
| Right parahippocampal gyrus (813) | ||||||
| Right hippocampus (521) | ||||||
| Right rolandic operculum (447) | ||||||
| Right insula (757) | ||||||
| Left posterior cingulate gyrus, BA 23 | −8,-48,32 | −3.880 | ~0 | 1866 | Left /Right precuneus (1056) | 30 out of 30 |
| Left/Right posterior cingulate gyrus (358) | ||||||
| Left/Right median cingulate/paracingulate gyri (452) | ||||||
| Right superior frontal gyrus, medial orbital, BA 11 | 4,34,-12 | −3.362 | 0.000474795 | 221 | Left/Right superior frontal gyrus, medial orbital (84) | 28 out of 30 |
| Left /Right gyrus rectus (23) | ||||||
| Left anterior cingulate/paracingulate gyri (18) | ||||||
Regions identified by meta-analysis of coordinates from Twenty one studies (voxelwise p < 0.005 and FWHM 20 mm).
Key: AD, Alzheimer’s disease; HC, healthy controls; MNI, Montreal Neurological Institute; SDM, signed differential mapping; GMV, Grey matter volume; BA, Brodmann area.