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. 2015 Mar 18;5:9. doi: 10.1186/s13395-015-0033-y

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© Vainshtein et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Elevated PGC-1α results in increased TFEB protein levels. (A-B) Blots and quantification TFEB protein level in TA muscle and in nuclear fraction of wild type (WT) and PGC-1α Tg (Tg) control (Con) and denervated (Den). (A) Representative blots. (B) Quantification of TFEB protein in TA muscle. *P < 0.05 significant difference between Con and Den. †P < 0.05 significant effect of genotype. GAPDH was used as loading control for whole muscle and histone 2 B (H2B) was used as nuclear loading control (n = 3 to 5 for all groups). GAPDH, glyceraldehyde 3-phosphate dehydrogenase. H2B, histone 2 B; Nuc. TFEB, nuclear transcription factor EB; TFEB, transcription factor EB.