Table 3.
Estimates of the number needed to screen and treat (NNS) for TB infection to prevent one case of active TB in the subsequent 5 years among groups by demographic and diabetes status in California
| Target population of TB screening and treatment | NNS base case | TB Infection prevalence a | Rate of progression to active TB a | ||
|---|---|---|---|---|---|
| High | Low | High | Low | ||
| All adults | 7,930 | 6,667 | 10,000 | 3,846 | 14,286 |
| All foreign-born adults | 1,526 | 1,136 | 2,128 | 763 | 2,941 |
| All adults with diabetes | 2,740 | 2,222 | 3,448 | 1,370 | 5,556 |
| U.S.-born adults with diabetes | 9,551 | 7,143 | 12,500 | 4,762 | 20,000 |
| Foreign-born adults with diabetes | 596 | 442 | 826 | 298 | 1,163 |
| Foreign-born adults with diabetes by location of birth | |||||
| Latin America | 741 | 526 | 877 | 370 | 1,493 |
| Southeast Asia/Pacific Islands | 296 | 206 | 361 | 148 | 585 |
| East Asia | 372 | 260 | 452 | 186 | 730 |
| South Asia | 335 | 234 | 408 | 168 | 662 |
| Europe | 2,221 | 1,493 | 3,448 | 1,111 | 4,545 |
| Africa/Middle East | 384 | 270 | 562 | 192 | 769 |
aHigh and low indicate the range of NNS using a range of TB infection prevalence and Rate of progression to active disease. See Additional file 1: Table S1 for inputs and ranges used.