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. 2015 Mar 25;16(1):242. doi: 10.1186/s12864-015-1464-x

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© Tizioto et al.; licensee Biomed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The mechanistic network of the inferred upstream regulator APOE . Genes presented in orange are related to genes up-regulated in the LRFI phenotype group. Genes presented in blue are related to genes down-regulated in LRFI animals. The intensity of the colors is related to fold change estimates. Arrows presented in orange, gray and yellow indicate activation, effect not predicted and inconsistency, respectively.