Skip to main content
. 2014 Nov 25;6(1):56–70. doi: 10.18632/oncotarget.2695

Figure 6. Epigenetic therapy sensitizes a patient derived model of adenocarcinoma to repeat treatment with irinotecan, but does not sensitize to cisplatin.

Figure 6

(A) LX7 bearing NOD/SCID mice were treated with 0.5 mg/kg Aza (sc) on days 1-3, 6-10, 13-17, and 1 mg/kg (ip) entinostat on days 3, 10, 17, or vehicle (n = 9 per arm). (B) NOD/SCID mice bearing LX7 tumors established from pooled vehicle (V) or epigenetic (E) pretreated tumors were treated with 10 mg/kg irinotecan (V-I and E-I) q4d × 3, 2 mg/kg cisplatin (V-C and E-C) q7d × 2, or saline vehicle (V-V and E-V). (C-D) Irinotecan tumors were allowed to grow following cessation of treatment. On day 32, mice were re-challenged with 10 mg/kg irinotecan on days 32, 36, and 40 (same dose and schedule as first cycle). * Two mice in the Vehicle – Irinotecan (V-I) arm were euthanized early (day 42 and 45 after final measurements) for n = 6 after day 45. Significance determined using a mixed effects model and REML. All growth curves depict mean tumor volume +/− SEM.