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. 2014 Dec 2;6(1):185–195. doi: 10.18632/oncotarget.2688

Figure 6. C98 delays myeloma tumor growth in xenograft mice models.

Figure 6

OPM2 (A) and JJN3 (B) were injected subcutaneously into nude mice with a density of 10 million cells/site/mouse. When tumors were palpable, mice (n = 5/group) were orally given C98 (80 mg/kg to OPM2 mice, 40 and 80 mg/kg to JJN3 mice) in PBS containing 10% Tween 80 and 10% DMSO daily for continuous 16 days. Tumor volumes were monitored every other day. (C) Tumor weight from the JJN3 model was measured at the end of the experiment. (D) JJN3 cells-derived tumor samples from each group were subject to immunoblotting analysis for the expression of PARP, p-AKT, t-AKT, and PTEN. GAPDH was used as a loading control.