Figure 1. Correlations between SULT1A1 expression and NSC-743380's anticancer activity.

A) Scattered plot for correlations of NSC-743380' 50% growth inhibition concentrations (GI₅₀) and SULT1A1 mRNA levels in NCI-60 cell lines (r = 0.56, p = 4.13 × 10⁻⁶). B) Sensitization of H1299 to NSC-743380 by transient transfection with a SULT1A1 expressing plasmid. H1299 lung cancer cells were transfected with plasmids expressing GFP and SULT1A1 for 24 hours and then treated with 1 μM NSC-743380 or dimethyl sulfoxide (DMSO) for 12 hours. The panel shows cell morphology under regular and fluorescent microscopes. Transfection with SULT1A1 alone did not induce cell death (see DMSO group), whereas NSC-743380 induced cell death in transfected cells only (green cells in the treated group).