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. 2014 Sep 25;6(1):471–483. doi: 10.18632/oncotarget.2509

Table 2. Pathways linked to the 16 significantly deregulated miRNAs.

KEGG pathway N° of miRNA p-value N° of target genes
Long-term potentiation 13 6.84E-22 33
ErbB signaling pathway 12 1.16E-15 35
Dilated cardiomyopathy 13 5.34E-14 36
ABC transporters 8 5.27E-12 20
Prostate cancer 13 2.15E-11 33
Glutamatergic synapse 13 1.71E-10 40
Neurotrophin signaling pathway 13 3.43E-10 42
Regulation of actin cytoskeleton 14 3.90E-10 65
Arrhythmogenic right ventricular cardiomyopathy [ARVC] 13 5.59E-10 31
Focal adhesion 14 3.69E-09 60
Hypertrophic cardiomyopathy [HCM] 12 5.80E-09 30
Axon guidance 13 9.22E-09 46
Ubiquitin mediated proteolysis 12 1.07E-08 45
Glioma 13 1.69E-08 27
Insulin signaling pathway 14 1.69E-08 43
Endometrial cancer 12 4.55E-07 20
B cell receptor signaling pathway 11 5.96E-07 26
Non-small cell lung cancer 12 7.85E-07 20
PI3K-Akt signaling pathway 14 1.36E-06 86
GnRH signaling pathway 12 1.80E-06 29
Progesterone-mediated oocyte maturation 12 1.80E-06 28
mTOR signaling pathway 12 2.29E-06 22
Endocytosis 12 2.84E-06 56
Acute myeloid leukemia 10 3.72E-06 20
Pancreatic cancer 13 4.62E-06 24
Amyotrophic lateral sclerosis 8 5.70E-06 18
Phosphatidylinositol signaling system 12 9.39E-06 29
Fc gamma R-mediated phagocytosis 12 1.80E-05 29
Calcium signaling pathway 12 1.87E-05 50
Bacterial invasion of epithelial cells 11 1.89E-05 24
Endocrine and other factor-regulated calcium reabsorption 7 1.97E-05 18
Dopaminergic synapse 14 1.97E-05 39
Small cell lung cancer 14 4.85E-05 26
TGF-beta signaling pathway 13 5.27E-05 25
Shigellosis 11 5.54E-05 21
Cholinergic synapse 14 6.70E-05 36
Gap junction 10 7.56E-05 26
Chronic myeloid leukemia 12 7.56E-05 24
Melanoma 11 7.66E-05 23
HIF-1 signaling pathway 14 7.66E-05 32
Colorectal cancer 11 7.84E-05 21
Long-term depression 11 0.00010297 22
Type II diabetes mellitus 8 0.000254913 16
MAPK signaling pathway 13 0.000254913 67
Oocyte meiosis 12 0.00028102 36
Gastric acid secretion 12 0.00028102 23
Inositol phosphate metabolism 10 0.000438238 20
Natural killer cell mediated cytotoxicity 12 0.000438238 39
Vascular smooth muscle contraction 13 0.00054281 34
Aldosterone-regulated sodium reabsorption 10 0.000675186 13
Pathways in cancer 15 0.000805191 88
Melanogenesis 12 0.001443074 27
RNA degradation 10 0.001527123 21
Taurine and hypotaurine metabolism 4 0.002484891 4
Renal cell carcinoma 11 0.002484891 22
Retrograde endocannabinoid signaling 13 0.002555835 32
T cell receptor signaling pathway 11 0.002611728 29
VEGF signaling pathway 11 0.002830415 19
Glycosylphosphatidylinositol[GPI]-anchor biosynthesis 6 0.003458651 9
Serotonergic synapse 11 0.004099713 30
Amphetamine addiction 11 0.004449922 23
Propanoate metabolism 7 0.005323316 10
GABAergic synapse 12 0.005836946 28
Protein processing in endoplasmic reticulum 14 0.00600624 43
Wnt signaling pathway 14 0.006229163 42
Cell cycle 12 0.006354843 33
Chemokine signaling pathway 14 0.006702432 45
Glycerophospholipid metabolism 12 0.008604037 26
Biotin metabolism 1 0.01053896 1
Carbohydrate digestion and absorption 9 0.01053896 12
Hepatitis B 14 0.01246892 40
Circadian rhythm 9 0.01363142 10
Osteoclast differentiation 13 0.01363142 33
Tight junction 13 0.01376918 35
Transcriptional misregulation in cancer 14 0.0144959 46
mRNA surveillance pathway 12 0.0145927 23
Adherens junction 12 0.03073926 23
Viral myocarditis 12 0.03463523 18
N-Glycan biosynthesis 10 0.03514185 15
Salmonella infection 12 0.04015256 21