Table 3. Focal Adhesion, HIF-1 and VEGF signaling pathways linked to the deregulated miRNAs.

KEGG pathway	N° of miRNA	miRNA	N° of target genes	target genes
Focal adhesion pathway	14	hsa-miR-122-5p hsa-miR-1271-5p hsa-miR-16-2-3p hsa-miR-1911-3p hsa-miR-30e-5p hsa-miR-3128 hsa-miR-328 hsa-miR-4302hsa-miR-514b-5p hsa-miR-548u hsa-miR-550a-3phsa-miR-628-5p hsa-miR-578 hsa-miR-573	60	ACTB TLN2 GSK3B PDGFRA ACTN2 ERBB2 ROCK1 ITGA9 ITGA8 PIK3CB CAV1 PIK3R2 RAP1A ROCK2 ITGA5 ITGA3 IGF1R EGFR CAV2 ITGA1 FYN SHC3 PTK2 PPP1R12A PIK3CD PIK3R3 DOCK1 MAPK8 ITGB1 PARVA RELN FLNB ACTN1 FLT1 PDK1 FLNA ITGA2 COL4A4 SOS1 ITGA10 RAC1 PRKCB LAMC1 SHC4 AKT3 PDGFC MYLK3 COL11A1 PIK3CA ITGA4 ITGA6 VAV3 PTEN MAPK1 RAP1B MYLK ILK COL4A1 ITGB3 PDGFA
HIF-1 signaling pathway	14	hsa-miR-122-5p hsa-miR-1271-5p hsa-miR-16-2-3p hsa-miR-1911-3p hsa-miR-30e-5p hsa-miR-3128 hsa-miR-328 hsa-miR-548u hsa-miR-4302 hsa-miR-514b-5p hsa-miR-550a-3p hsa-miR-573 hsa-miR-578 hsa-miR-628-5p	32	CAMK2D ERBB2 CAMK2G PIK3CB CUL2 IFNGR2 PIK3R2 ANGPT2 IGF1R EGFR RPS6KB2 CAMK2A PIK3CD PIK3R3 EIF4E FLT1 CYBB PRKCB AKT3 PIK3CA IFNG SLC2A1 MKNK1 PFKFB2 EDN1 MTOR ALDOA MAPK1 CREBBP RPS6KB1 EGLN1 PFKFB3
VEGF signaling pathway	11	hsa-miR-122-5p hsa-miR-1271-5p hsa-miR-1911-3p hsa-miR-30e-5p hsa-miR-3128 hsa-miR-328 hsa-miR-4302 hsa-miR-548u hsa-miR-573 hsa-miR-578 hsa-miR-628-5p	19	NRAS PIK3CB PIK3R2 KRAS PPP3CA PTK2 NFAT5 PIK3CD PIK3R3 PPP3CB NFATC2 RAC1 PPP3R1 PRKCB AKT3 PIK3CA NFATC3 MAPK1 PPP3R2