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. 2015 Apr 1;9:66. doi: 10.3389/fncel.2015.00106

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Copyright © 2015 Brignone, Lanciotti, Camerini, De Nuccio, Petrucci, Visentin and Ambrosini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of specific amino acid consensus motifs found in the human megalencephalic leukoencephalopathy with subcortical cysts (MLC1) protein sequence. The picture shows consensus motifs for post-translational modifications (glycosylation and phosphorylation), protein–protein or protein–lipid interactions (protein dimerization and cav-1 and cholesterol binding sites) and protein trafficking signals (endoplasmic reticulum export and retention signals), either putative (empty circles), or functionally identified (filled circles) (modified from Lanciotti et al., 2012).