Table 1.
Lipid composition of the liposomes
| Formulation | Molar ratio of lipids
|
|||
|---|---|---|---|---|
| EPC | Chol | SA | aPEG-DSPE | |
| LipE | 1 | – | – | – |
| LipEC | 0.8 | 0.2 | – | – |
| LipES | 0.8 | – | 0.2 | – |
| LipECS I | 0.4 | 0.3 | 0.3 | – |
| LipECS II | 0.64 | 0.16 | 0.2 | – |
| LC-LipECS | 0.6 | 0.15 | 0.19 | 0.05 |
Abbreviations: aPEG-DSPE, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000]; Chol, cholesterol; EPC, egg phosphatidylcholine; LC-LipECS, Long-circulating aPEG-DSPE:EPC:Chol:SA liposome; LipE, EPC liposome; LipEC, EPC:Chol liposome; LipECS I, EPC:Chol:SA liposome (low concentration of EPC); LipECS II, EPC:Chol:SA liposome (high concentration of EPC); LipES, EPC:SA liposome; SA, stearylamine.