Figure 2.

Dissociation between behavior and BP regulation in circadian-disrupted mice (Yang et al., 2012). PPARγ knockout mice (KO) and their littermate controls (Ctrl) were kept under regular light/dark cycles. Locomotor activity (A), mean arterial pressure (B) and heart rate (C) were recorded using radiotelemetry. Both KO (blue box) and control mice display obvious day/night variation in locomotor activity. However, KO mice cannot maintain normal variations in BP and heart rate (red boxes) as control mice. *p < 0.05; ns, not significant.