Table 1.
The outcome of COH in terms of oocytes and embryos.
| COH protocol | Statistical significance at P < 0.05 | |||
|---|---|---|---|---|
| Mild protocol | GnRH antagonist protocol (GnRH-ant) | GnRH agonist protocol (GnRH-a) | ||
| Oocyte aspirations | 166 | 1096 | 1111 | |
|
| ||||
| Average female age (years) | 31.8 ± 3.2 | 31.8 ± 3.4 | 32.0 ± 3.4 | / |
|
| ||||
| Baseline FSH (mIU/mL) | 6.4 ± 1.8 | 6.7 ± 2.1 | 6.9 ± 2.0 | / |
|
| ||||
| Oocytes (per cycle) | 1500 (9.0 ± 5.2) | 10249 (9.4 ± 5.0) | 12004 (10.8 ± 5.6) |
P = 0.0001 (mild versus GnRH-a), P < 0.0001 (GnRH-ant versus GnRH-a) |
|
| ||||
| Immature oocytes (%) | 240 (16.0%) | 1602 (15.6%) | 1687 (14.1%) |
P = 0.0420 (mild versus GnRH-a), P = 0.0010 (GnRH-ant versus GnRH-a) |
|
| ||||
| Fertilized oocytes, 2PN (%) | 865 (57.7%) | 5440 (53.1%) | 6235 (51.9%) |
P = 0.0009 (mild versus GnRH-ant), P < 0.0001 (mild versus GnRH-a) |
|
| ||||
| Embryos (%) | 845 (56.3%) | 5198 (50.7%) | 5968 (49.7%) |
P < 0.0001 (mild versus GnRH-ant), P < 0.0001 (mild versus GnRH-a) |
|
| ||||
| Embryos (per cycle) | 5.1 ± 3.7 | 4.7 ± 3.3 | 5.4 ± 3.5 | P < 0.0001 (GnRH-ant versus GnRH-a) |
|
| ||||
| Embryo transfers (%) | 151 (91.0%) | 1017 (92.8%) | 1006 (90.5%) | / |
|
| ||||
| Transferred embryos (per ET) | 1.6 ± 0.5 | 1.6 ± 0.5 | 1.7 ± 0.4 |
P = 0.0022 (mild versus GnRH-a), P < 0.0001 (GnRH-ant versus GnRH-a) |
|
| ||||
| Cycles with embryo freezing (%) | 50 (30.1%) | 317 (28.9%) | 210 (18.9%) |
P = 0.0008 (mild versus GnRH-a), P < 0.0001 (GnRH-ant versus GnRH-a) |
|
| ||||
| Frozen embryos (per cycle) | 0.8 ± 1.4 | 0.9 ± 1.8 | 0.5 ± 1.3 |
P = 0.0243 (mild versus GnRH-a), P < 0.0001 (GnRH-ant versus GnRH-a) |
|
| ||||
| OHSS | 0 | 4 | 12 | / |