Table 4. Gene expression values relevant to pyruvate metabolism and the TCA cycle.
Gene | FC Pat. 2 | FC Pat. 3 | FC Pat. 4 | FC Pat. 5 | FC Pat. 6 | FC Pat. 9 | FC Pat. 10 | FC Pat. 11 | FC Pat. 12 | Average FC | p-value (from TDSIT) |
---|---|---|---|---|---|---|---|---|---|---|---|
Over-expressed | |||||||||||
PDK1 | 16.23 | 17.82 | 3.90 | 5.37 | 6.22 | 9.76 | 6.17 | 9.34 | 15.34 | 10.02 | 2.07E-06 |
SLC16A3 | 7.83 | 6.55 | 4.92 | 3.74 | 9.35 | 8.46 | 2.55 | 10.06 | 10.35 | 7.09 | 2.99E-06 |
SLC16A1 | 4.19 | 5.10 | 2.99 | 2.11 | 2.10 | 1.04 | 5.24 | 5.73 | 3.50 | 3.56 | 2.68E-04 |
LDHA | 2.99 | 2.84 | 3.21 | 2.72 | 2.99 | 2.61 | 3.23 | 2.35 | 4.13 | 3.01 | 3.34E-08 |
Under-expressed | |||||||||||
SUCLG1 | −4.57 | −5.25 | −4.71 | −5.26 | −5.22 | −4.41 | −2.62 | −5.85 | −6.42 | −4.80 | 7.88E-08 |
PDHB | −1.76 | −3.69 | −1.59 | −2.49 | −3.63 | −2.16 | −2.03 | −2.89 | −4.51 | −2.59 | 4.65E-05 |
OGDH | −2.14 | −1.43 | −1.44 | −3.24 | −1.77 | −3.23 | −5.35 | −1.68 | −3.64 | −2.40 | 5.03E-04 |
PDHA1 | −1.53 | −2.65 | −4.50 | −1.35 | −3.19 | −2.18 | −2.37 | −2.85 | −2.09 | −2.38 | 1.04E-04 |
SUCLG2 | −1.66 | −2.84 | −2.13 | −1.72 | −3.00 | −2.92 | −1.92 | −1.98 | −3.14 | −2.30 | 9.97E-06 |
DLST | 1.21 | −2.03 | −1.49 | −2.51 | −2.06 | −4.19 | −1.63 | −2.62 | −3.11 | −2.08 | 1.60E-03 |
FH | −1.65 | −3.89 | −1.62 | −2.13 | −2.21 | −2.60 | −1.94 | −1.32 | −1.77 | −2.03 | 1.48E-04 |
Unchanged | |||||||||||
PDK4 | 2.18 | 1.31 | 1.96 | 1.37 | −1.71 | 1.98 | 2.11 | 1.67 | −1.02 | 1.46 | 3.01E-02 |
LDHB | −2.27 | −1.35 | −1.84 | −2.05 | −3.05 | −1.92 | −1.74 | −1.98 | −1.18 | −1.87 | 1.43E-04 |
IDH2 | 1.29 | −1.86 | −2.65 | −1.98 | −2.21 | −3.29 | −2.49 | −1.44 | −1.38 | −1.86 | 2.51E-03 |
PDK2 | −1.33 | −1.57 | −1.97 | −1.56 | −1.29 | −1.79 | −1.62 | −1.75 | −3.31 | −1.73 | 3.56E-04 |
ACO2 | −1.23 | −2.03 | −2.28 | −1.66 | −1.24 | −3.15 | −1.45 | −1.47 | −1.78 | −1.73 | 6.57E-04 |
SDHD | −2.31 | −1.11 | −1.27 | −1.21 | −1.71 | −1.82 | −1.37 | −1.80 | −3.42 | −1.67 | 2.49E-03 |
DLAT | 1.05 | −2.46 | −1.66 | 2.73 | −1.65 | −2.07 | −1.83 | −1.67 | −3.46 | −1.55 | 7.51E-02 |
SDHB | −1.48 | −1.99 | −1.49 | −1.23 | −1.46 | −1.78 | −1.02 | −2.09 | −1.58 | −1.53 | 4.53E-04 |
SDHC | 1.72 | −1.41 | −1.78 | −2.08 | −1.03 | −2.39 | −1.74 | −1.60 | −2.05 | −1.52 | 2.08E-02 |
IDH3B | −1.51 | −1.20 | −1.98 | −1.23 | −4.85 | −1.23 | −1.13 | 1.05 | −1.33 | −1.50 | 3.74E-02 |
DLD | −1.24 | −1.16 | −1.94 | −1.03 | −1.64 | −2.18 | −1.23 | −1.46 | −1.85 | −1.48 | 1.93E-03 |
SUCLA2 | −1.26 | 1.19 | −1.31 | 1.09 | −1.37 | −1.32 | −1.23 | −2.23 | −4.15 | −1.44 | 5.43E-02 |
MDH2 | −1.05 | −1.07 | −1.30 | −1.48 | −1.40 | −1.52 | −2.07 | −1.49 | −1.15 | −1.36 | 2.32E-03 |
SDHA | 1.01 | 1.14 | −1.87 | −1.88 | 1.10 | −1.71 | 1.00 | −1.66 | −1.68 | −1.33 | 3.25E-02 |
IDH3G | −1.21 | −1.17 | −1.28 | −1.20 | 1.10 | −1.47 | −2.07 | −1.34 | −1.24 | −1.29 | 8.11E-03 |
CS | −1.46 | 1.12 | −1.52 | −1.26 | −1.34 | −1.06 | 1.04 | −1.02 | 1.22 | −1.12 | 1.54E-01 |
PDHX | 1.63 | −1.02 | −1.21 | −1.12 | −1.60 | −1.23 | −1.11 | −1.27 | −1.20 | −1.12 | 2.17E-01 |
IDH3A | 1.89 | −1.09 | −1.81 | −1.42 | 1.28 | 1.04 | −1.44 | −1.42 | 1.56 | −1.04 | 7.70E-01 |
PDK3 | 1.29 | −1.36 | 1.11 | −1.08 | −1.52 | 1.47 | −1.02 | −1.22 | 1.10 | −1.02 | 8.21E-01 |