Table 1.
Comparison of protein concentrations (pg/mL) of growth factors and cytokines between controls and baseline pregnancy samples.
| Healthy control (N = 11) | Pregnancy baseline (N = 16) | ||||||
|---|---|---|---|---|---|---|---|
| Median | Min. | Max. | Median | Min. | Max. | P | |
| Higher in pregnancy | |||||||
| GROα | 341.6 | 243.3 | 742.6 | 1018.6 | 424.4 | 3208 | <0.001 |
| PDGF-AA | 563.8 | 340.9 | 923.7 | 10740.6 | 2181 | >ULD | <0.001 |
| TGFα | 1.8 | <LLD | 33.3 | 11.7 | 2.7 | 78.4 | 0.002 |
| EGF | 24.8 | 8.6 | 178.2 | 489.4 | 14.6 | 1506 | 0.003 |
| PDGF-AB/BB | 3410.4 | 493 | 7482 | 10760.7 | 3650 | >ULD | 0.005 |
| Higher in controls | |||||||
| Eotaxin | 330.9 | 166.3 | 651 | 36.8 | 9.8 | 136.9 | <0.001 |
| sCD40L | 424.7 | 132.7 | 1423 | 29.2 | 0 | 1583 | 0.004 |
| IP-10 | 400.2 | 198.6 | 1271 | 162.7 | 57.8 | 380.7 | 0.009 |
| IL-17 | 14.8 | 2.2 | 161.6 | 5.5 | <LLD | 46.9 | 0.03 |
| IL-6 | 7.9 | <LLD | 82 | <LLD | <LLD | 34.3 | 0.03 |
| IL-13 | 21.3 | <LLD | 95 | <LLD | <LLD | 37.3 | 0.05 |
| MCP-1 | 492.6 | 176.9 | 1043 | 335.2 | 80.5 | 1002 | 0.05 |
| Nonstatistically significant differences | |||||||
| IL1-ra | 81.4 | <LLD | 2087 | 21 | <LLD | 430.4 | 0.07 |
| IFNγ | 62.7 | 3.4 | 170 | 11.8 | 1.3 | 221.6 | 0.08 |
| IL-12p70 | 5.7 | <LLD | 48.6 | 0.6 | <LLD | 18.9 | 0.09 |
| IL-2 | 5 | <LLD | 50.8 | 0.1 | <LLD | 45.7 | 0.1 |
| sIL2-ra | <LLD | <LLD | 52.1 | 7.2 | <LLD | 71.7 | 0.1 |
| VEGF | 476.4 | 5.7 | 1399 | 189.5 | <LLD | 466.1 | 0.1 |
| IL-12p40 | 48.6 | <LLD | 155.7 | 2.4 | <LLD | 333.8 | 0.2 |
| IL-3 | <LLD | <LLD | 5.1 | <LLD | <LLD | 1.4 | 0.2 |
| IL-4 | <LLD | <LLD | 98.3 | <LLD | <LLD | 31.1 | 0.2 |
| MCP-3 | 10.4 | <LLD | 43.8 | 15.9 | <LLD | 76.5 | 0.2 |
| RANTES | 6093.6 | 1590 | >ULD | 22264.8 | 1696 | >ULD | 0.2 |
| IFNα2 | 47 | <LLD | 378.6 | 22.8 | 5 | 719.3 | 0.3 |
| IL-5 | 0.3 | <LLD | 1.1 | 0.6 | <LLD | 1.8 | 0.3 |
| IL-9 | <LLD | <LLD | 27 | <LLD | <LLD | 9.9 | 0.3 |
| Fractalkine | 106.6 | <LLD | 2157 | 96.8 | <LLD | 514.6 | 0.4 |
| MIP-1β | 45.1 | <LLD | 366 | 50.1 | 27.6 | 196.5 | 0.4 |
| TNFβ | 0.2 | <LLD | 20.5 | <LLD | <LLD | 36.6 | 0.4 |
| G-CSF | 25.1 | 7.3 | 220.6 | 29.2 | 6.3 | 619.8 | 0.5 |
| IL-7 | <LLD | <LLD | 29 | 1.3 | <LLD | 219.3 | 0.5 |
| IL-8 | 12.8 | 4.8 | 45.2 | 10.8 | 1.4 | 22.8 | 0.5 |
| FGF-2 | 28.8 | 11.8 | 103.5 | 24.7 | 5.9 | 75.1 | 0.6 |
| GM-CSF | 94.1 | 14.3 | 456.3 | 65.7 | 23.7 | 3337 | 0.6 |
| Il-1β | <LLD | <LLD | 25.2 | <LLD | <LLD | 7.1 | 0.6 |
| FLT3-ligand | 7 | <LLD | 84.1 | <LLD | <LLD | 72.8 | 0.7 |
| IL-15 | <LLD | <LLD | 11.1 | 0.9 | <LLD | 12.1 | 0.8 |
| IL-10 | <LLD | <LLD | 19.1 | <LLD | <LLD | 17.1 | 0.9 |
| IL-1ra2 | 3 | <LLD | 34.4 | <LLD | <LLD | 48.2 | 0.9 |
| MDC/CCL22 | 1460.4 | 676 | 4049 | 1440.8 | 239.1 | 3665 | 0.9 |
| MIP-1α | 58.9 | 11.6 | 129 | 51.1 | 15.3 | 289 | 0.9 |
| TNFα | 3.8 | <LLD | 35.9 | 6.4 | 0.4 | 97.7 | 0.9 |
EGF = epidermal growth factor, FGF-2 = fibroblast growth factor-2, G-CSF = granulocyte colony stimulating factor, GM-CSF = granulocyte macrophage colony stimulating factor, GRO-a = growth-related oncogene alpha, IFN = interferon, IL = interleukin, IL-1ra = IL-1 receptor antagonist, IP-10 = interferon-gamma induced protein 10, MCP = monocyte chemotactic protein, MDC = macrophage-derived chemokine, MIP = macrophage inflammatory protein, PDGF = platelet-derived growth factor, RANTES = regulated on activation, normal T cell expressed and secreted, sCD40L = soluble CD40 ligand, sIL2-ra = soluble IL-2 receptor alpha, TGF-a = transforming growth factor alpha, TNF = tumor necrosis factor, and VEGF = vascular endothelial growth factor.