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. 2014 Nov 7;24(6):1528–1539. doi: 10.1093/hmg/ddu564

Figure 1.

Figure 1.

DNAm landscape of the X chromosome by CpG density and chromatin state. (A) Average male versus average female DNAm at X-linked CpGs demonstrates two major clusters of DNAm. Each grey square represents a single CpG (n = 8527); thick black kernel density lines help visualize the number of CpGs. (B) Box and whisker plots of the average female (F = light grey) and male (M = dark grey) DNAm based on CpG density (number of CpGs, HC: n = 3725, ICshore: n = 849, IC: n = 1402, LC: n = 2551). Significance based on a Wilcox test comparison of means is as follow: *P-values 0.05–0.001, **P-values 0.001–2.2E−16 and ***P-values < 2.2E − 16. (C) Summary of the influence of CpG density and chromatin marks on different X-linked genomic regions. Xi≤≥Xa indicates that there is not a clear relationship explaining the interaction between DNAm, X inactivation density and chromatin marks.