TABLE 3.
Significant associations of SLC2A9 SNPs with serum uric acid concentrations1
| Genotype-specific means of serum uric acid concentrations5 |
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| SNP | Base-pair position2 | MGA P value | Minor allele/frequency | Risk allele3 | Effect size,4 % | 11 | 12 | 22 |
| rs11723388 | 9804900 | 3.3 × 10−16 | A/0.26 | G | 10 | 4.21 (2.3) | 5.02 (2.1) | 5.54 (2.5) |
| rs11721501 | 9798233 | 5.7 × 10−16 | A/0.26 | G | 9.9 | 4.17 (2.3) | 5.02 (2.1) | 5.55 (2.5) |
| rs6843466 | 9537003 | 1.2 × 10−15 | A/0.49 | G | 9.6 | 4.67 (1.7) | 5.32 (1.6) | 5.75 (1.9) |
| rs17251963 | 9751659 | 1.3 × 10−15 | G/0.25 | A | 9.7 | 4.12 (1.5) | 5.04 (1.6) | 5.53 (1.7) |
| rs13129697 | 9536065 | 1.4 × 10−15 | A/0.49 | A | 9.6 | 5.74 (1.9) | 5.29 (1.6) | 4.66 (1.7) |
| rs7696983 | 9604927 | 1.5 × 10−15 | A/0.26 | G | 9.3 | 4.03 (2.3) | 5.06 (1.6) | 5.51 (2.5) |
| rs13113918 | 9607591 | 1.5 × 10−15 | A/0.26 | G | 9.3 | 4.03 (2.3) | 5.06 (1.6) | 5.51 (2.5) |
| rs7683856 | 9610045 | 1.5 × 10−15 | A/0.26 | G | 9.3 | 4.03 (2.3) | 5.06 (1.6) | 5.51 (2.5) |
| rs9991278 | 9611763 | 1.5 × 10−15 | A/0.26 | G | 9.3 | 4.03 (2.3) | 5.06 (2.1) | 5.51 (2.5) |
| rs13111638 | 9605988 | 2.1 × 10−15 | A/0.25 | G | 9.1 | 3.97 (1.4) | 5.07 (1.6) | 5.49 (1.7) |
| rs4481233 | 9565177 | 2.4 × 10−15 | A/0.24 | G | 9.0 | 3.96 (2.3) | 5.04 (1.6) | 5.51 (1.8) |
| rs1978274 | 9854185 | 2.5 × 10−15 | C/0.29 | A | 9.5 | 4.28 (2.3) | 5.06 (2.1) | 5.56 (2.5) |
| rs7669607 | 9606899 | 2.4 × 10−15 | A/0.26 | G | 8.5 | 4.03 (2.3) | 5.06 (1.6) | 5.51 (2.5) |
| rs9991278 | 9611817 | 3.0 × 10−15 | A/0.26 | G | 9.1 | 4.03 (2.3) | 5.07 (2.1) | 5.51 (2.5) |
| rs11723439 | 9560917 | 3.5 × 10−15 | A/0.25 | G | 8.6 | 3.98 (1.3) | 5.08 (1.7) | 5.49 (1.7) |
| rs4697745 | 9914179 | 5.1 × 10−15 | A/0.27 | G | 9.1 | 4.24 (1.6) | 5.04 (1.6) | 5.55 (1.8) |
| rs7675964 | 994134 | 5.7 × 10−15 | G/0.49 | G | 9.2 | 5.73 (1.9) | 5.28 (1.6) | 4.69 (1.7) |
| rs938552 | 9925524 | 7.0 × 10−15 | A/0.41 | G | 8.9 | 4.53 (1.6) | 5.23 (1.7) | 5.60 (1.7) |
| rs6449213 | 9994215 | 1.3 × 10−14 | G/0.25 | A | 8.6 | 4.02 (1.4) | 5.05 (1.6) | 5.50 (1.7) |
| rs12510549 | 9885815 | 2.0 × 10−14 | G/0.26 | A | 8.5 | 4.32 (1.6) | 5.04 (1.6) | 5.53 (1.8) |
The top 20 associations are shown. Estimates of the allele frequencies and their SEs were obtained by using the software program Sequential Oligogenic Linkage Analysis Routines (SOLAR), version 7.6.2 (32). The final model included age, age-squared, sex, age × sex, age-squared × sex, BMI z score, and systolic blood pressure as covariates. MGA, measured genotype analysis; SLC2A9, solute carrier family 2, member 9; SNP, single nucleotide polymorphism.
Position based on NCBI Genome Build 36.3.
Risk allele = allele that is associated with increased serum uric acid concentrations (mg/dL).
Effect size = proportion of residual phenotypic variance explained by the SNP.
1 = minor allele; 2 = major allele.